South San Francisco Homes for Sale

Welcome to South San Francisco, a vibrant city nestled in the heart of San Mateo County, California. Known as the "Industrial City," South San Francisco boasts a rich history and a dynamic community spirit. With its stunning views of the San Francisco Bay and the majestic hills that surround it, this city offers a perfect blend of urban convenience and natural beauty.

South San Francisco is strategically located just minutes from the bustling metropolis of San Francisco, making it a desirable destination for both professionals and families alike. The city's well-planned neighborhoods are home to a diverse population, creating a warm and welcoming atmosphere. Residents enjoy easy access to a variety of parks, recreational facilities, and a bustling downtown area filled with shops, restaurants, and cultural attractions.

For those looking to make South San Francisco their home, there are a variety of homes for sale that cater to different lifestyles and budgets. From charming single-family homes with spacious yards to modern condos with stunning views, the real estate market here is as diverse as its residents. Families will appreciate the excellent schools and safe neighborhoods, while young professionals will love the proximity to major employers and public transportation options.

Whether you are seeking a cozy retreat or a vibrant community, South San Francisco has something for everyone. Explore the homes for sale today and discover the perfect place to call your own in this dynamic city. Embrace the lifestyle that South San Francisco offers, where every day feels like a new adventure!

Newest South San Francisco Homes for Sale

$1,549,000

3 Beds ⋅ 2 Baths ⋅ ML82060428 MLS

Welcome to this spacious and versatile 3-bedroom, 2-bathroom home in South San Francisco. The open floor plan flows beautifully between the living, dining, and updated kitchen areas, creating the perfect setting for family gatherings and entertaining. The dining area also features a unique indoor BBQ grill. Off the garage is an additional room and full bathroom with a separate entrance, offering great flexibility for guests, extended family, a home office, or additional living space. Enjoy a large backyard with plenty of room for entertaining, gardening, or relaxing. Conveniently located near Highway 280, shopping plazas, restaurants, and more. A wonderful opportunity to make this versatile home your own!

328 Alta Mesa Drive, South San Francisco

Listing courtesy of Mouna Kayed from Compass. 650-784-1682

$1,598,000

5 Beds ⋅ 3 Baths ⋅ ML82060781 MLS

Welcome to 2231 Delvin Way, a beautifully maintained 5 BD, 3 BA home offering approximately 2,000 sqft in desirable Westborough. Thoughtfully updated while retaining its original charm, this inviting home ft refinished original hardwood floors & baseboards, plantation shutters, picturesque windows, fresh interior & exterior paint, updated electrical, and new light fixtures. An expansive LR welcomes you w/ recessed lighting, cozy fireplace, and charming partition separating the living & dining areas. The fully remodeled kitchen ft premium cabinetry, granite countertops, top-of-the-line SS appliances, and wine refrigerator. The open layout flows seamlessly into the family room, where sliding glass doors lead to low-maintenance backyard, ideal for relaxing & entertaining. Convenient main-level bedroom & full bathroom offer flexibility for guests, office, or multigenerational living. Upstairs 3 spacious guest bedrooms w/ new ceiling lights and generous primary suite w/ updated ensuite bathroom. Abundant closet space provides excellent storage. Completing the home is a 2-car garage. Meticulously cared for and move-in ready, this Westborough residence offers comfortable living and timeless appeal in a sought-after location, close to parks, shopping, dining, and everyday conveniences.

2231 Delvin Way, South San Francisco

Listing courtesy of from KW Advisors. 650-888-0153

$1,098,000

3 Beds ⋅ 1 Baths ⋅ ML82060772 MLS

Beautifully reimagined and move-in ready, 774 Alta Loma Dr offers modern style, thoughtful upgrades, and inviting single-story living in South San Francisco. This 3-bedroom, 1-bath home features approximately 1,220 sq ft of bright, refreshed living space designed for both comfort and everyday functionality. Step inside to discover new flooring and windows throughout, fresh interior paint, stylish lighting, and a beautifully renovated kitchen featuring new cabinetry, countertops, backsplash, and stainless steel appliances. The remodeled bathroom adds a fresh, contemporary touch to the home. Beyond its beautiful finishes, meaningful upgrades including a newly installed furnace and thermostat, updated electrical panel, new exterior and sliding glass doors, and a new garage door enhance comfort and functionality. Fresh exterior paint and updated landscaping enhance the homes curb appeal and create a welcoming first impression. Conveniently located near shopping, dining, parks, and major commute routes, this thoughtfully updated home brings together style, comfort, and convenience. This South San Francisco gem is not to be missed!

774 Alta Loma Drive, South San Francisco

Listing courtesy of from Aspire Homes. 408-320-8584

$998,000

2 Beds ⋅ 1 Baths ⋅ ML82060689 MLS

The best of Brentwood has just arrived! 214 Wildwood Dr. is one of those homes that has not just been lived in... it's been loved it's entire life! Meticulously maintained and renovated, this two-bedroom, one-bath home is freshly painted and features gleaming hardwood floors, a remodeled kitchen with the space and functionality for a world-class chef, a remodeled bathroom, a spacious yard for outdoor enjoyment, a large living room with fireplace, a dining room, and more that will have you ready to make this house your home! Enjoy plenty of on- and off-street parking, plus a one-car garage. Ideally located within easy walking distance of incredible shopping, dining, and transportation. This is not one of those homes you simply see... its a home you will feel! Make sure you don't miss it!

214 Wildwood, South San Francisco

Listing courtesy of Alex Lehr from Guide Real Estate. 650-766-5300

$1,680,000

3 Beds ⋅ 3 Baths ⋅ ML82059726 MLS

This expansive 3,160 sq. ft. single-family home sits in convenient South San Francisco with beautiful partial mountain views. It features an updated kitchen, partially refreshed baths, and two flexible bonus rooms ready to serve as an office, gym, nursery, theater, or extra bedrooms. The open floor plan is designed for relaxed everyday living, with a formal dining room well suited to entertaining. A rare extra-large 3-car garage (not included in the square footage) and washer and dryer connections on both the main floor and in the garage add to everyday convenience. Substantial living space and Peninsula convenience in one package. Welcome to your new home!

541 Chestnut Avenue, South San Francisco

Listing courtesy of Eric Lin from KW Advisors. 415-690-8434

$998,888

2 Beds ⋅ 1 Baths ⋅ ML82060106 MLS

Located in South San Francisco, this 2-bedroom, 1-bathroom home offers 1,050 sq ft of living space on a 4,675 sq ft lot. The ground floor bedroom and laminate flooring throughout provide a practical layout. The kitchen features modern appliances including a dishwasher, garbage disposal, electric oven, and refrigerator. The bathroom includes a primary stall shower with tile finishes. The living room is enhanced by a fireplace, adding a cozy focal point to the space. Laundry facilities include an electricity hookup (110V). Additional interior features include a dining area and a video/audio system. The property includes a one-car garage and is located within the South San Francisco Unified elementary school district. No cooling system or pool is present.

208 Camaritas Avenue, South San Francisco

Listing courtesy of Bessie Marfori from Intero Real Estate Services. 650-483-2281

$1,478,000

3 Beds ⋅ 2 Baths ⋅ ML82059340 MLS

Beautifully refreshed and thoughtfully expanded, this impressive 3-bedroom, 2-bath residence offers approximately 1,870 square feet of inviting living space designed for both everyday comfort and effortless entertaining. A fresh interior and exterior color palette creates a crisp, sophisticated feel, complemented by newly installed and beautifully refinished hardwood flooring throughout. The updated kitchen features new countertops and appliances, offering a stylish and functional centerpiece for the home. Expanded over the years, the residence offers a wonderfully versatile floor plan with a spacious family room and enclosed patio providing additional areas to gather, entertain or simply unwind. Generous living spaces and an easy flow throughout the home create a sense of openness rarely found in a traditional three-bedroom residence. The transformation continues outdoors, where newly landscaped front and rear yards enhance the homes curb appeal and create attractive settings for outdoor dining, entertaining and relaxation. Freshly updated, exceptionally spacious and ready to enjoy, 343 Alta Mesa Drive presents a wonderful opportunity to experience elevated Peninsula living with the space and flexibility to make it truly your own.

343 Alta Mesa Drive, South San Francisco

Listing courtesy of Stephan A. Marshall from Christie's International Real Estate Sereno. 650-455-1528

$1,248,000

3 Beds ⋅ 4 Baths ⋅ ML82059314 MLS

Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.

643 Grand Avenue, South San Francisco

Listing courtesy of Jill Penna from Christie's International Real Estate Sereno. 415-244-8630

$980,000

3 Beds ⋅ 1 Baths ⋅ ML82059151 MLS

Opportunity awaits at 22 Sonora Avenue! This 3-bedroom, 1-bath home offers an efficient two-level floor plan and plenty of potential for its next owner. The main level features a light-filled living room with multiple windows, an eat-in kitchen, and one bedroom. Upstairs, you'll find two additional bedrooms connected by an open landing area beneath charming pitched ceilings. An attached one-car garage and generous backyard provide added space and possibilities. Owned by the same family for many years, the home is ready for its next chapter and an opportunity for a buyer to renovate and make it their own. Convenient South San Francisco location near shopping, transportation, and everyday amenities. Bring your vision and imagine the possibilities!

22 Sonora Avenue, South San Francisco

Listing courtesy of Jennifer Doak from Intero Real Estate Services. 408-799-3737

$1,798,000

4 Beds ⋅ 4 Baths ⋅ ML82058691 MLS

Nestled in the highly coveted Westborough Hills of South San Francisco, welcome to this spacious and inviting 4-bedroom, 3.5-bath well crafted home for comfortable living and entertainment in a three-level setting. Featuring generous living spaces with very high ceilings, well-appointed bedrooms, and modern remodeled bathrooms, this home offers the perfect blend of style, functionality, and convenience. The open and welcoming layout provides plenty of room for everyday living, while the four bedrooms offer flexibility for family, guests, or home office, with easy accessibility to a ground level bedroom and full bath. Top floor offers sweeping panoramic views where you can enjoy breathtaking sunrises every morning over the city skyline. The home offers a large back deck and a private estate entrance and security. Don't miss an opportunity to own property in the booming Biotech capital of California, just 10 minutes away midst the best part of the city and 10 minutes from scenic Highway 1 and ocean beaches. Regular sale with a clean and clear title history for an easy close of escrow.

7222 Shannon Park Court, South San Francisco

Listing courtesy of Ravi Sen from Maxim Solution Realty Corporation. 650-444-6623

$939,000

2 Beds ⋅ 1 Baths ⋅ ML82058178 MLS

Welcome to 157 A Street, a charming South San Francisco home where classic character meets thoughtful updates. Beautifully refreshed with new interior and exterior paint and updated fixtures throughout, this inviting residence is polished, welcoming, and ready to enjoy from day one. Inside, natural light and original character create a warm sense of home. Beautiful parquet hardwood floors bring richness and charm to the living spaces, while the corner fireplace creates an inviting focal point and a cozy place to gather. The sunny eat in kitchen offers a cheerful setting for morning coffee, casual meals, and everyday living, while two comfortable bedrooms and a well-appointed bath complete the home's thoughtfully designed interior. Outside, a private yard offers a lovely extension of the living space, with room to relax, garden, or entertain. An attached garage with laundry hookups adds everyday convenience. Ideally situated near downtown South San Francisco, with easy access to shopping, dining, BART, Caltrain, SFO, and major commuter routes, 157 A Street offers an appealing combination of character, convenience, and move in ready comfort in the heart of the Peninsula.

157 A Street, South San Francisco

Listing courtesy of Travis Conte from Berkshire Hathaway HomeServices DrysdaleProperties. 650-520-5753

$1,200,000

3 Beds ⋅ 1 Baths ⋅ ML82057159 MLS

Welcome to 107 Mulberry this charming home features living room wth fire place, shutters throughout home, original hardwood floors, It offers 3 Bedrooms 1 Bathroom, The bathroom has been recently remodeled with two car detached garage, long paved driveway for plenty of addl. parking. eat -in kitchen, new SS appliances, separate laundry room adjacent to kitchen. freshly painted interior & exterior. Blocks away is the Orange Memorial Park.

107 Mulberry Avenue, South San Francisco

Listing courtesy of Jorge Franco from Franco Real Estate Group. 650-703-9580

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